Creating new possibilities for oral drug delivery

Very often, potential drugs are either abandoned or formulated into less than desirable dosage forms because they exhibit poor water solubility. This can lead to inadequate or erratic absorption. In fact, it’s estimated that 40% to 60% of all new chemical entities fall into this category. MicroSolv can rescue many water insoluble drugs and convert them into viable products.


 

An absorbed emulsifying system

Emulsion-based systems offer solubilization and bioavailability advantages. Their applicability is limited, however, because drug-containing emulsions are inherently unstable, while self-emulsifying formulations are often incompatible with capsule shell compositions.

Patented MicroSolv technology overcomes these challenges. Absorption of the emulsion onto a solid carrier allows for the manufacture of tablets and capsules using conventional pharmaceutical equipment and processes.

MicroSolv technologies can be used with emulsions, microemulsions, self-emulsifying drug delivery systems (SEDDS) and self-microemulsifying drug delivery systems (SMEDDS).

Quick facts:

  • Improved bioavailability
  • Ability to overcome food effects
  • Dosage forms: ODTs, tablets, capsules
  • Ease of manufacture

MicroSolv formulations improve dissolution rate similar to an emulsified drug

The following in vitro dissolution graph shows how MicroSolv formulations have similar dissolution rates to emulsions. MicroSolv technology can accommodate drug strengths up to 50 mg.


 

Overview

Creating new possibilities for oral drug delivery

Very often, potential drugs are either abandoned or formulated into less than desirable dosage forms because they exhibit poor water solubility. This can lead to inadequate or erratic absorption. In fact, it’s estimated that 40% to 60% of all new chemical entities fall into this category. MicroSolv can rescue many water insoluble drugs and convert them into viable products.


 

Technical Notes

An absorbed emulsifying system

Emulsion-based systems offer solubilization and bioavailability advantages. Their applicability is limited, however, because drug-containing emulsions are inherently unstable, while self-emulsifying formulations are often incompatible with capsule shell compositions.

Patented MicroSolv technology overcomes these challenges. Absorption of the emulsion onto a solid carrier allows for the manufacture of tablets and capsules using conventional pharmaceutical equipment and processes.

MicroSolv technologies can be used with emulsions, microemulsions, self-emulsifying drug delivery systems (SEDDS) and self-microemulsifying drug delivery systems (SMEDDS).

Quick facts:

  • Improved bioavailability
  • Ability to overcome food effects
  • Dosage forms: ODTs, tablets, capsules
  • Ease of manufacture

Case Study

MicroSolv formulations improve dissolution rate similar to an emulsified drug

The following in vitro dissolution graph shows how MicroSolv formulations have similar dissolution rates to emulsions. MicroSolv technology can accommodate drug strengths up to 50 mg.