Your product goes wherever patients go

OraSolv allows patients to take their medication whenever they need it, wherever they might be. Blister packaging makes OraSolv conveniently portable. Rapid oral disintegration allows patients to take it discreetly, without water. Taste-masking and flavorings make for a more pleasant experience. For these reasons, OraSolv products have become very popular among patients and physicians.

Placed in the mouth, OraSolv products will disintegrate rapidly without chewing.  As the tablet disintegrates, drug microparticles are released and swallowed as a slurry or suspension. Complete dissolution and systemic absorption occurs in the GI tract. Typically, the pharmacokinetics are matched to the reference product.

Enhanced tablet disintegration

OraSolv technology delivers taste-masked drug microparticles through a
formulation that enhances tablet disintegration. When this formulation is exposed
to saliva in the mouth, carbon dioxide is generated, causing a pleasant sensation
for the patient and stimulating further saliva production, which aids disintegration.

OraSolv technology is compatible with CIMA taste-masking techniques and
PakSolv® proprietary packaging. Proprietary packaging technology
results in a container closure system that protects tablets from light, moisture,
and breakage.

Quick facts:

  • Oral administration, GI tract absorption
  • Dose range: 1 mg – 750 mg
  • Disintegration time: 10 – 30 seconds
  • Customized release profiles (IR, SR, MR and enteric-coated)
  • Tablet size: 1/4” – 5/8”
  • Flavor, color and debossing options to match your brand identity
  • Bitter drugs can be taste-masked
  • Blister packaging (including child-resistant options)


All globally acceptable ingredients:

  • Filler
  • Disintegrant
  • Flavor
  • Sweetener
  • Lubricant
  • Colorant, if required
  • Effervescent components

Preferred by patients

Patients prefer Remeron® SolTab®* formulation compared to conventional
tablets. In a global patient survey with over 3000 participants, 86% had a positive
impression, with 64% indicating a preference over conventional tablets. Reasons
cited were ease of use, taste, ability to take without water, and at anytime.

Reference: Poster, ECNP meeting, October 2005 Reference: Geriatrics and Aging 2005, ‘Rapid dissolving antidepressant enhances compliance in 50 percent of patients, ongoing global preference survey confirms patients prefer Remeron’, vol. 8, no. 3, p. 47.

CIMA delivery technologies can help your product win patient preference and
market share. OraSolv ODT technology has been instrumental in bringing
numerous enhanced products to market.

  • FazaClo® (clozapine)
  • Orapred ODT®** (prednisolone sodium phosphate)


  * Remeron® SolTab® is a registered trademark of N.V. Organon.
** Orapred ODT® is a registered trademark of BioMarin.

Overview

Your product goes wherever patients go

OraSolv allows patients to take their medication whenever they need it, wherever they might be. Blister packaging makes OraSolv conveniently portable. Rapid oral disintegration allows patients to take it discreetly, without water. Taste-masking and flavorings make for a more pleasant experience. For these reasons, OraSolv products have become very popular among patients and physicians.

Placed in the mouth, OraSolv products will disintegrate rapidly without chewing.  As the tablet disintegrates, drug microparticles are released and swallowed as a slurry or suspension. Complete dissolution and systemic absorption occurs in the GI tract. Typically, the pharmacokinetics are matched to the reference product.

Technical Notes

Enhanced tablet disintegration

OraSolv technology delivers taste-masked drug microparticles through a
formulation that enhances tablet disintegration. When this formulation is exposed
to saliva in the mouth, carbon dioxide is generated, causing a pleasant sensation
for the patient and stimulating further saliva production, which aids disintegration.

OraSolv technology is compatible with CIMA taste-masking techniques and
PakSolv® proprietary packaging. Proprietary packaging technology
results in a container closure system that protects tablets from light, moisture,
and breakage.

Quick facts:

  • Oral administration, GI tract absorption
  • Dose range: 1 mg – 750 mg
  • Disintegration time: 10 – 30 seconds
  • Customized release profiles (IR, SR, MR and enteric-coated)
  • Tablet size: 1/4” – 5/8”
  • Flavor, color and debossing options to match your brand identity
  • Bitter drugs can be taste-masked
  • Blister packaging (including child-resistant options)


All globally acceptable ingredients:

  • Filler
  • Disintegrant
  • Flavor
  • Sweetener
  • Lubricant
  • Colorant, if required
  • Effervescent components

Case Study

Preferred by patients

Patients prefer Remeron® SolTab®* formulation compared to conventional
tablets. In a global patient survey with over 3000 participants, 86% had a positive
impression, with 64% indicating a preference over conventional tablets. Reasons
cited were ease of use, taste, ability to take without water, and at anytime.

Reference: Poster, ECNP meeting, October 2005 Reference: Geriatrics and Aging 2005, ‘Rapid dissolving antidepressant enhances compliance in 50 percent of patients, ongoing global preference survey confirms patients prefer Remeron’, vol. 8, no. 3, p. 47.

CIMA delivery technologies can help your product win patient preference and
market share. OraSolv ODT technology has been instrumental in bringing
numerous enhanced products to market.

  • FazaClo® (clozapine)
  • Orapred ODT®** (prednisolone sodium phosphate)


  * Remeron® SolTab® is a registered trademark of N.V. Organon.
** Orapred ODT® is a registered trademark of BioMarin.